Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pax6  paired box 6   (Synonyms: 1500038E17Rik, AEY11, Dey, Dickie's small eye, Gsfaey11, Pax-6)
Results	Reference
1*	J:155881 Bedogni F, Hodge RD, Nelson BR, Frederick EA, Shiba N, Daza RA, Hevner RF, Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology. Gene Expr Patterns. 2010 Jan;10(1):9-15
1	J:258293 Divya TS, Lalitha S, Parvathy S, Subashini C, Sanalkumar R, Dhanesh SB, Rasheed VA, Divya MS, Tole S, James J, Regulation of Tlx3 by Pax6 is required for the restricted expression of Chrnalpha3 in Cerebellar Granule Neuron progenitors during development. Sci Rep. 2016 Jul 25;6:30337
1	J:193584 Duan D, Fu Y, Paxinos G, Watson C, Spatiotemporal expression patterns of Pax6 in the brain of embryonic, newborn, and adult mice. Brain Struct Funct. 2013 Mar;218(2):353-72
1	J:99610 Ekonomou A, Kazanis I, Malas S, Wood H, Alifragis P, Denaxa M, Karagogeos D, Constanti A, Lovell-Badge R, Episkopou V, Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1. PLoS Biol. 2005 Jun;3(6):e186
1	J:119485 Friedel RH, Kerjan G, Rayburn H, Schuller U, Sotelo C, Tessier-Lavigne M, Chedotal A, Plexin-B2 controls the development of cerebellar granule cells. J Neurosci. 2007 Apr 4;27(14):3921-32
1	J:118795 Fuerst PG, Rauch SM, Burgess RW, Defects in eye development in transgenic mice overexpressing the heparan sulfate proteoglycan agrin. Dev Biol. 2007 Mar 1;303(1):165-80
1	J:286645 Gilet JG, Ivanova EL, Trofimova D, Rudolf G, Meziane H, Broix L, Drouot N, Courraud J, Skory V, Voulleminot P, Osipenko M, Bahi-Buisson N, Yalcin B, Birling MC, Hinckelmann MV, Kwok BH, Allingham JS, Chelly J, Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny. Hum Mol Genet. 2020 Mar 27;29(5):766-784
1*	J:308606 Hamada N, Iwamoto I, Kawamura N, Nagata KI, Heterotrimeric G-protein, Gi1, is involved in the regulation of proliferation, neuronal migration, and dendrite morphology during cortical development in vivo. J Neurochem. 2021 May;157(4):1167-1181
1*	J:94457 Haubst N, Berger J, Radjendirane V, Graw J, Favor J, Saunders GF, Stoykova A, Gotz M, Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development. Development. 2004 Dec;131(24):6131-40
1	J:217045 Heng YH, McLeay RC, Harvey TJ, Smith AG, Barry G, Cato K, Plachez C, Little E, Mason S, Dixon C, Gronostajski RM, Bailey TL, Richards LJ, Piper M, NFIX regulates neural progenitor cell differentiation during hippocampal morphogenesis. Cereb Cortex. 2014 Jan;24(1):261-79
1	J:203743 Higginbotham H, Guo J, Yokota Y, Umberger NL, Su CY, Li J, Verma N, Hirt J, Ghukasyan V, Caspary T, Anton ES, Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation. Nat Neurosci. 2013 Aug;16(8):1000-7
1	J:296116 Hirose T, Cabrera-Socorro A, Chitayat D, Lemonnier T, Feraud O, Cifuentes-Diaz C, Gervasi N, Mombereau C, Ghosh T, Stoica L, Bacha JDA, Yamada H, Lauterbach MA, Guillon M, Kaneko K, Norris JW, Siriwardena K, Blaser S, Teillon J, Mendoza-Londono R, Russeau M, Hadoux J, Ito S, Corvol P, Matheus MG, Holden KR, Takei K, Emiliani V, Bennaceur-Griscelli A, Schwartz CE, Nguyen G, Groszer M, ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration. J Clin Invest. 2019 Apr 15;129(5):2145-2162
1	J:282066 Huang R, Yuan DJ, Li S, Liang XS, Gao Y, Lan XY, Qin HM, Ma YF, Xu GY, Schachner M, Sytnyk V, Boltze J, Ma QH, Li S, NCAM regulates temporal specification of neural progenitor cells via profilin2 during corticogenesis. J Cell Biol. 2020 Jan 6;219(1)
1	J:339078 Huilgol D, Levine JM, Galbavy W, Wang BS, He M, Suryanarayana SM, Huang ZJ, Direct and indirect neurogenesis generate a mosaic of distinct glutamatergic projection neuron types in cerebral cortex. Neuron. 2023 Aug 16;111(16):2557-2569.e4
1	J:242258 Iida A, Iwagawa T, Baba Y, Satoh S, Mochizuki Y, Nakauchi H, Furukawa T, Koseki H, Murakami A, Watanabe S, Roles of histone H3K27 trimethylase Ezh2 in retinal proliferation and differentiation. Dev Neurobiol. 2015 Sep;75(9):947-60
1	J:275532 Ivanova EL, Gilet JG, Sulimenko V, Duchon A, Rudolf G, Runge K, Collins SC, Asselin L, Broix L, Drouot N, Tilly P, Nusbaum P, Vincent A, Magnant W, Skory V, Birling MC, Pavlovic G, Godin JD, Yalcin B, Herault Y, Draber P, Chelly J, Hinckelmann MV, TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis. Nat Commun. 2019 May 13;10(1):2129
1	J:120581 Jensen J, Heller RS, Funder-Nielsen T, Pedersen EE, Lindsell C, Weinmaster G, Madsen OD, Serup P, Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes. 2000 Feb;49(2):163-76
1	J:175146 Kumbasar A, Plachez C, Gronostajski RM, Richards LJ, Litwack ED, Absence of the transcription factor Nfib delays the formation of the basilar pontine and other mossy fiber nuclei. J Comp Neurol. 2009 Mar 1;513(1):98-112
1*	J:309351 Lalitha S, Basu B, Surya S, Meera V, Riya PA, Parvathy S, Das AV, Sivakumar KC, Nelson-Sathi S, James J, Pax6 modulates intra-retinal axon guidance and fasciculation of retinal ganglion cells during retinogenesis. Sci Rep. 2020 Sep 30;10(1):16075
1	J:337597 Li J, Jiang H, Mu Y, Wei Z, Ma A, Sun M, Zhao J, Zhu C, Chen X, SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex. iScience. 2023 Jul 21;26(7):107042
1	J:217544 Lv X, Jiang H, Liu Y, Lei X, Jiao J, MicroRNA-15b promotes neurogenesis and inhibits neural progenitor proliferation by directly repressing TET3 during early neocortical development. EMBO Rep. 2014 Dec;15(12):1305-14
1*	J:159510 Maiorano NA, Mallamaci A, Promotion of embryonic cortico-cerebral neuronogenesis by miR-124. Neural Dev. 2009;4:40
1	J:104327 Matsumoto S, Banine F, Struve J, Xing R, Adams C, Liu Y, Metzger D, Chambon P, Rao MS, Sherman LS, Brg1 is required for murine neural stem cell maintenance and gliogenesis. Dev Biol. 2006 Jan 15;289(2):372-83
1	J:253963 Moon KH, Kim HT, Lee D, Rao MB, Levine EM, Lim DS, Kim JW, Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development. Dev Cell. 2018 Jan 8;44(1):13-28.e3
1*	J:180189 Mori N, Kuwamura M, Tanaka N, Hirano R, Nabe M, Ibuki M, Yamate J, Ccdc85c encoding a protein at apical junctions of radial glia is disrupted in hemorrhagic hydrocephalus (hhy) mice. Am J Pathol. 2012 Jan;180(1):314-27
1	J:306310 Nasu M, Shimamura K, Esumi S, Tamamaki N, Formation of dorsal-ventral axis of the pallium derived from mouse embryonic stem cells. Biochem Biophys Res Commun. 2020 Mar 26;524(1):117-122
1	J:142509 Oron-Karni V, Farhy C, Elgart M, Marquardt T, Remizova L, Yaron O, Xie Q, Cvekl A, Ashery-Padan R, Dual requirement for Pax6 in retinal progenitor cells. Development. 2008 Dec;135(24):4037-47
1	J:299727 Panagiotakos G, Haveles C, Arjun A, Petrova R, Rana A, Portmann T, Pasca SP, Palmer TD, Dolmetsch RE, Aberrant calcium channel splicing drives defects in cortical differentiation in Timothy syndrome. Elife. 2019 Dec 23;8:e51037
1	J:71196 Panchision DM, Pickel JM, Studer L, Lee SH, Turner PA, Hazel TG, McKay RD, Sequential actions of BMP receptors control neural precursor cell production and fate. Genes Dev. 2001 Aug 15;15(16):2094-110
1	J:164377 Pereira JD, Sansom SN, Smith J, Dobenecker MW, Tarakhovsky A, Livesey FJ, Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15957-62
1*	J:206928 Piper M, Barry G, Harvey TJ, McLeay R, Smith AG, Harris L, Mason S, Stringer BW, Day BW, Wray NR, Gronostajski RM, Bailey TL, Boyd AW, Richards LJ, NFIB-Mediated Repression of the Epigenetic Factor Ezh2 Regulates Cortical Development. J Neurosci. 2014 Feb 19;34(8):2921-30
1	J:286609 Tait CM, Chinnaiya K, Manning E, Murtaza M, Ashton JP, Furley N, Hill CJ, Alves CH, Wijnholds J, Erdmann KS, Furley A, Rashbass P, Das RM, Storey KG, Placzek M, Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal. PLoS Biol. 2020 Mar;18(3):e3000470
1	J:194044 Walcher T, Xie Q, Sun J, Irmler M, Beckers J, Ozturk T, Niessing D, Stoykova A, Cvekl A, Ninkovic J, Gotz M, Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation. Development. 2013 Mar;140(5):1123-36
1	J:333924 Wang S, Fu Y, Miyata T, Matsumoto S, Shinoda T, Itoh K, Harada A, Hirotsune S, Jin M, Functional Cooperation of alpha-Synuclein and Tau Is Essential for Proper Corticogenesis. J Neurosci. 2022 Sep 14;42(37):7031-7046
1	J:186253 Wu QF, Yang L, Li S, Wang Q, Yuan XB, Gao X, Bao L, Zhang X, Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell. 2012 Jun 22;149(7):1549-64
1	J:241111 Wu ZQ, Li D, Huang Y, Chen XP, Huang W, Liu CF, Zhao HQ, Xu RX, Cheng M, Schachner M, Ma QH, Caspr Controls the Temporal Specification of Neural Progenitor Cells through Notch Signaling in the Developing Mouse Cerebral Cortex. Cereb Cortex. 2017 Feb 01;27(2):1369-1385